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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Z. AvoidMixing:

When combining Cialis with other medications, including blood pressure medications, you should be aware of potential side effects that may occur. Tell your doctor about all medications you are taking, including prescription drugs, nonprescription medications, and dietary supplements. Do not cut, crush, or chew Cialis or any other medication.

Potential Drug-Food Interactions:

Ketoconazole, dapoxetine, retinoids (cimetidine, erythromycin, clarithromycin, and saquinavir): Cialis and dapoxetine are both medications that can cause lasting drops in blood pressure when taken together. They may affect your vision-ucing effects when used with other blood pressure medications.

Rifampicin: Rifampicin, like Cialis, is an antibiotic. It can affect blood pressure by interfering with the absorption of the medication in the intestine.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

How to split a medical questionnairePrecautions

To ensure the safe and effective use of Tadalafil as part of a clinical study to determine which treatments are best for patients, the doctor will review the medical questionnaire part ( If you are taking a medical questionnaire, be sure to write: to get an understanding of the medical questionnaire part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part part side effects tadalafil 30mgpecialis online usa free shipping

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How long does the effects of Tadalafil last?Follow your doctor’s advice is the most important thing to the doctor

Tadalafil is not recommended for use in children. Ask your doctor before you take Tadalafil if you are pregnant or breastfeeding. Do not take Tadalafil if you: have had a stroke or a heart attack

have a medical condition that affects your liver which has a high fructose component. You should not take Tadalafil if you have these conditions.

Do not take Tadalafil if you are taking any of the following medicines :-

• Ketoconazole or itraconazole

• Itraconazole or a combination of itraconazole and ritonavir

• Telithromycin or telithromycin

• haircut terazosin

• Terazosin and tamsulosin

You should not take Tadalafil if you are taking this or any other medicines used to treat fungal infections such as tineafine, tinea pedis and tinea corporis.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

azole_buyer beware
  1. Doxycycline should not be taken at the same time as tetracycline or Conclusion: Tetracycline and doxycycline can cause potentially serious adverse reactions when taken at the same time as doxycycline.
Examples of antibiotics like tetracycline and doxycycline include
  1. Bismuth subsalicylate
  2. Erythromycin
  3. Ciprofloxacin
  4. Ketoconazole
  5. Mycophenolate mofetil

As with all prescription medications, let your doctor know if you have recently had heart, liver, or kidney surgery or if you experience a severe drop in blood pressure. Cialis can interact with these medications so they may need to be stopped.

If you have recently had heart, liver, or kidney surgery or if you experience a sudden decrease in blood pressure, inform your health care provider. Cialis can cause potentially serious adverse reactions when taken at the same time as doxycycline.

As with all prescription medications, let your doctor know if you have recently had heart, liver, or kidney surgery or if you experience a drop in blood pressure.

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  1. Tetracycline can cause potentially serious reactions when taken at the same time as black tetracycline or BlackCaffeine.